Maze Therapeutics Chief Medical Officer Dumps Entire Direct Stake in the Company for $255,000

Robert Izquierdo, The Motley Fool

Fri, September 11, 2026 at 11:07 PM GMT+3 4 min read

MAZE -0.89%

Harold Bernstein, President of Research and Development and Chief Medical Officer at Maze Therapeutics, Inc. (NASDAQ:MAZE), sold 9,705 shares of common stock on September 4, 2026, according to an SEC Form 4 filing.

Transaction summary

Transaction value based on SEC Form 4 weighted average sale price ($26.22).

Key questions

What was the nature of this transaction?
The sale was a routine execution under a Rule 10b5-1 trading plan. This arrangement allows insiders to set up a pre-determined schedule for selling stock to manage personal liquidity and portfolio diversification.
How does this sale affect Bernstein's ownership stake?
Following the transaction, the insider holds zero shares of common stock directly. The reported ownership percentage after the completion of this 9,705-share disposition stands at zero.
What is the recent performance context for Maze Therapeutics?
The stock was priced at $26.21 at the September 4, 2026 market close, down from a 52-week high of $53.65 reached in March of 2026. The transaction was executed at a weighted average price of $26.22 per share.
What are the primary clinical programs for the company?
Maze Therapeutics is a clinical stage biopharmaceutical company developing small molecule precision medicines for kidney and metabolic diseases. Its lead programs include MZE829, which is in a phase II clinical trial for APOL1 kidney disease, and MZE782 for the treatment of phenylketonuria.

Company Overview

Company Snapshot

Maze Therapeutics develops small molecule precision medicines targeting kidney and metabolic diseases, with lead programs including MZE829, an oral APOL1 inhibitor in Phase II clinical trials for APOL1 kidney disease, and MZE782, an oral small molecule inhibitor in Phase II-ready development for phenylketonuria treatment.
The company operates as a clinical-stage biopharmaceutical enterprise generating revenue through research collaborations and development agreements while advancing its proprietary drug candidates through clinical development stages.
Maze Therapeutics targets patients with rare genetic kidney and metabolic disorders, focusing on underserved patient populations with limited therapeutic options and significant unmet medical needs.

Maze Therapeutics is a clinical-stage biopharmaceutical company with a market cap of $1.50 billion, investing substantially in clinical development. The company's strategy centers on leveraging precision medicine approaches to develop targeted therapies for genetically defined kidney and metabolic diseases, positioning itself to address significant therapeutic gaps in rare disease treatment.

What this transaction means for investors

Chief Medical Officer Harold Bernstein's Sept. 4 sale of Maze Therapeutics stock resulted in the total liquidation of his direct holdings. This action is considered a non-discretionary transaction, since it was executed as part of a pre-established Rule 10b5-1 plan adopted on Sept. 29 of 2025.

Even so, the disposition at a weighted average price of $26.22 per share does not instill investor confidence in Maze Therapeutics stock, especially after shares crumbled about 50% from their 52-week high of $53.65 in March. Shares fell after Maze Therapeutics announced an offering of 5.5 million shares for $23.50 per share in April.

Bernstein's liquidation only adds to concerns about the company's future. However, a separate filing shows he owns derivative securities in the form of 160,662 stock options and 20,000 restricted stock units as of Sept. 1. This indicates he maintains a sizable equity stake in the company, ensuring his continued alignment with shareholder interests.

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Robert Izquierdo has no position in any of the stocks mentioned. The Motley Fool has no position in any of the stocks mentioned. The Motley Fool has a disclosure policy.

Maze Therapeutics Chief Medical Officer Dumps Entire Direct Stake in the Company for $255,000 was originally published by The Motley Fool